Search results for "skin delivery"

showing 3 items of 3 documents

Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

2017

Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107 nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~24 mPa/s) as compared to transfersomes (~1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in th…

3003SwinePharmaceutical ScienceMedicine (miscellaneous)02 engineering and technology01 natural sciencesMicechemistry.chemical_compoundDrug Delivery Systemsmaterials science (all)skin deliveryGeneral Materials ScienceSkinchemistry.chemical_classificationSkin repairSmall-angle X-ray scatteringBilayerVesicleAnti-Inflammatory Agents Non-SteroidalPolysaccharides BacterialPolymer021001 nanoscience & nanotechnologymedicine.anatomical_structureMolecular MedicineFemale0210 nano-technologytransfersomesSkin AbsorptionBiomedical EngineeringgellanBioengineeringAdministration Cutaneous010402 general chemistryIn vivo studiesDermisIn vivoSAXS analysismedicineAnimalsgellan; In vivo studies; rheological studies; SAXS analysis; skin delivery; transfersomes; bioengineering; medicine (miscellaneous); molecular medicine; biomedical engineering; materials science (all); 3003rheological studiesFlavonoidsInflammationWound Healing0104 chemical sciencesAnimals NewbornchemistryLiposomesBiophysicsNanoparticlesBaicalin
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Glycerosomes:investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances

2017

Glycerosomes were formulated using 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC), diclofenac sodium salt and 10, 20 or 30% glycerol in the water phase, while corresponding liposomes were prepared with the same amount of DMPC and diclofenac, without glycerol. The aim of the present work was to evaluate the effect of the used phospholipid on vesicle features and ability to favour diclofenac skin deposition by comparing these results with those found in previous works performed using hydrogenated soy phosphatidylcholine (P90H) and dipalmitoylphosphatidylcholine (DPPC). Liposomes and glycerosomes were multilamellar, liposomes being smaller (72±6nm). Interactions among glycerol, phospho…

liposomes3003skindimyristoylphosphatidylcholinePhospholipidPharmaceutical Science02 engineering and technologyrehological studies010402 general chemistry01 natural sciencesDSCchemistry.chemical_compoundglycerosomesdrug delivery systemsPhosphatidylcholineGlycerolskin deliveryDSC; glycerosomes; rehological studies; SAXS; skin delivery; animals; diclofenac; dimyristoylphosphatidylcholine; liposomes; skin; swine; drug delivery systems; skin absorption; 3003LiposomeChromatographyBilayerVesicletechnology industry and agricultureswineDiclofenac SodiumSAXS021001 nanoscience & nanotechnologyskin absorption0104 chemical sciencesanimalsdiclofenacchemistryDipalmitoylphosphatidylcholinelipids (amino acids peptides and proteins)0210 nano-technology
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Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topi…

2019

New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (&le

PhospholipidPharmaceutical Sciencelcsh:RS1-44102 engineering and technology030226 pharmacology & pharmacyArticleclotrimazolelcsh:Pharmacy and materia medica03 medical and health scienceschemistry.chemical_compound0302 clinical medicineIn vivophospholipid vesiclesX-raysCandida albicansElectron microscopymedicineGlycerolskin deliveryCandida albicansco-solventsPhospholipidsChromatographybiologyClotrimazoleSmall-angle X-ray scatteringVesicle021001 nanoscience & nanotechnologybiology.organism_classification<i>Candida albicans</i>Microscòpia electrònicachemistryTransmission electron microscopyfungal infectionsRaigs X0210 nano-technologyFosfolípidsmedicine.drugPharmaceutics
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